Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation
نویسندگان
چکیده
منابع مشابه
Archaeal Histones, Nucleosomes, and Transcription Initiation
Methanobacterium thermoautotrophicum and Metha-nobacterium formicicum, and five in Methanococcus and Charles J. Daniels Department of Microbiology jannaschii, two of which are plasmid-encoded (Bult et al., 1996; Grayling et al., 1996). In most cases, the primary sequences of the archaeal histones within one species are more similar to each other than to the sequences of histones in other Archae...
متن کاملConditions for positioning of nucleosomes on DNA.
Positioning of nucleosomes along a eukaryotic genome plays an important role in its organization and regulation. There are many different factors affecting the location of nucleosomes. Some can be viewed as preferential binding of a single nucleosome to different locations along the DNA and some as interactions between neighboring nucleosomes. In this study, we analyze positioning of nucleosome...
متن کاملCritical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair
The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has previously been reported, the molecular mechanism involved and its relationship with other histone modifications remain largely unknown. Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134...
متن کاملActive DNA demethylation mediated by DNA glycosylases.
Active DNA demethylation is involved in many vital developmental and physiological processes of plants and animals. Recent genetic and biochemical studies in Arabidopsis have demonstrated that a subfamily of DNA glycosylases function to promote DNA demethylation through a base excision-repair pathway. These specialized bifunctional DNA glycosylases remove the 5-methylcytosine base and then clea...
متن کاملActive DNA demethylation in plants and animals.
Active DNA demethylation regulates many vital biological processes, including early development and locus-specific gene expression in plants and animals. In Arabidopsis, bifunctional DNA glycosylases directly excise the 5-methylcytosine base and then cleave the DNA backbone at the abasic site. Recent evidence suggests that mammals utilize DNA glycosylases after 5-methylcytosine is oxidized and/...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: 2041-1723
DOI: 10.1038/s41467-021-21227-y